Comparing Analysis Methods for Mutation-Accumulation Data
نویسندگان
چکیده
منابع مشابه
Comparing analysis methods for mutation-accumulation data.
THE genomic deleterious mutation rate (U) and the different algorithms to locate maxima (or minima) in the multidimensional parameter space. ML employs nudistribution of mutational effects for fitness, f(s), merical integration to compute likelihood of data as a are important parameters for several theoretical issues function of U and f(s) and combines grid searches with in evolution (Charleswo...
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We simulated single-generation data for a fitness trait in mutation-accumulation (MA) experiments, and we compared three methods of analysis. Bateman-Mukai (BM) and maximum likelihood (ML) need information on both the MA lines and control lines, while minimum distance (MD) can be applied with or without the control. Both MD and ML assume gamma-distributed mutational effects. ML estimates of the...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.167.1.551